Targeting glucose metabolism for healthy aging

Targeting glucose metabolism for healthy aging

Advancing age is the greatest single risk factor for numerous chronic diseases. Thus, the ability to target the aging process can facilitate improved healthspan and potentially lifespan. Lack of adequate glucoregulatory control remains a recurrent theme accompanying aging and chronic disease, while numerous longevity interventions result in maintenance of glucoregulatory control. In this review...

Targeting glucose metabolism for cancer therapy

Cellular transformation is associated with the reprogramming of cellular pathways that control proliferation, survival, and metabolism. Among the metabolic changes exhibited by tumor cells is an increase in glucose metabolism and glucose dependence. It has been hypothesized that targeting glucose metabolism may provide a selective mechanism by which to kill cancer cells. In this minireview, we ...

The Effects of Aging on Glucose Metabolism

Type 2 diabetes mellitus is the most common chronic metabolic disease/disorder in the elderly. The prevalence and incidence of impaired glucose tolerance and diabetes mellitus increase with aging. In Taiwan, the prevalence of diabetes mellitus increases with age and is approximately 20% in those aged 65 years or older. The incidence of diabetes mellitus is also increasing in Taiwan. In an epide...

Overview of glucose metabolism and aging.

Targeting glucose metabolism in patients with cancer.

Nearly a century ago, Otto Warburg made the astute observation that the metabolic properties of cancer cells differ markedly from those of normal cells. Several decades passed before the concept of exploiting cancer cell metabolism came into clinical practice with the advent of chemotherapy, the underlying principle of which is to target rapidly dividing cells by interfering with critical proce...